St. Louis is an independent city and inland port in the U.S. state of Missouri. The city developed along the western bank of the Mississippi River, which forms Missouri’s border with Illinois. In 2010, St. Louis had a population of 319,294; a 2015 estimate put the population at 315,685, making it the 60th-most populous U.S. city and the second-largest city in Missouri after Kansas City. St. Louis was founded in 1764 by fur traders Pierre Laclède and Auguste Chouteau, and named after Louis IX of France.

The economy of St. Louis relies on service, manufacturing, trade, transportation of goods, and tourism. The city is home to several major corporations, including Anheuser-Busch, Express Scripts, Peabody Energy, Ameren, Ralcorp, Monsanto, and Sigma-Aldrich, as well as a large medical and research community. St. Louis has two professional sports teams: the St. Louis Cardinals of Major League Baseball and the St. Louis Blues of the National Hockey League. The city is commonly identified with the 630-foot tall Gateway Arch in Downtown St. Louis.

Notable people from St. Louis MO include Eberhard Anheuser (1805–1880), Lou Brock (MLB), Adolphus Busch (1839–1913),
Adolphus Busch III (1891–1946), August Anheuser Busch, Sr. (1865–1934), Gussie Busch (August Anheuser Busch, Jr.) (1899–1989), August Busch III (born 1937), August Busch IV (born 1964), Kate Capshaw (actress), Chip Caray (MLB),
Harry Caray (1914–1998), Skip Caray (MLB).

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